The national network is organized into four regions. (map) Libraries in each region belong to their own regional conference. Regions hold their own (or in some years, combined) conferences every other year, on the odd year. Each region also holds a business meeting at each NLS Biennial Conference, held every other year on the even year.

2023 Regional Conferences
The 2023 Western Regional Conference will take place from April 25-27th 2023, in Sacramento at the Braille and Talking Book Library, headquartered at the California State Library.

2023 Northern-Southern Regional Conference will take place May 2-4th in Daytona, Florida

The 2023 Midlands Conference will be held May 16-18 in Grand Rapids, Michigan.

2022 NLS Biennial Conference
Virtual, May 17-19

2021 Regional Conferences
2021 Western/Midlands Conference, Virtual, May 11-13

2020 NLS Biennial Conference
Virtual, December 1-3

2019 Regional Conferences
2019 Midland/Northern Conference, New York, NY, April 8-10
2019 Western/Southern Conference, San Antonio TX, May 7-9

2018 NLS Biennial Conference
Nashville, TN

2017 Regional Conferences
2017 Western/Southern Conference, Santa Fe, NM, May 9-11
2017 Midlands/Northern Conference, Ann Arbor, MI, June 6-8

2016 NLS Biennial Conference
2016 NLS Biennial Conference, San Francisco, CA, April 3-7

2015 Regional Conferences
2015 Tri-Regional Conference, Indianapolis, IN, June 9-11
2015 Western Conference, Sacramento, CA, May 12-14

2014 NLS Biennial Conference
Oklahoma City, OK, May 4-8

2013 Regional Conferences
2013 Tri-Regional Conference, Pittsburgh, PA, May 7-9
2013 Western Conference, Salem, OR, May 14–16

2012 NLS Biennial Conference
2012 Newport, RI, May 20-24

2011 Regional Conferences
2011 Midlands/Southern Conference, Louisville, KY
2011 Northern Conference, Washington, DC
2011 Western Conference, Denver, CO

2010 NLS Biennial Conference
2010 Des Moines, IA, May 16-20

Regional Conference Meeting Sites 1971-2015
Regional Conference Sites 1971-2015